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C0297
Sigma
Monoclonal Anti-Caldesmon antibody produced in mouse
clone C21, ascites fluid
| MDL number: | MFCD00164554 |
Description
| Immunogen | chicken caldesmon |
| Specificity | The antibody is directed against an epitope near the carboxy-terminus, Ca2+/calmodulin and F-actin binding site of caldesmon.1 Using ELISA, the antibody is able to inhibit caldesmon binding to Ca2+/calmodulin and F-actin. By immunoblotting,2 the antibody shows broad species reactivity to non-muscle caldesmon of mammalian cells. |
Properties
| antibody form | ascites fluid |
| clone | C21 (monoclonal) |
| contains | 15 mM sodium azide |
| species reactivity | mammals |
| application(s) | immunoblotting: suitable |
| indirect ELISA: 1:2,500 | |
| isotype | IgG1 |
| Gene Information | human ... CALD1(800) |
| rat ... Cald1(25687) | |
| mouse ... Cald1(109624) | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| WGK Germany | NWG |
References
| Cited Reference | 1. Lin, J.J.C., et al. Hybridoma 7, 273, (1988) Abstract |
| 2. Gimona, M., et al. FEBS Lett. 274, 159, (1990) Abstract | |
| reference | Draeger, A., et al. FEBS Lett. 291, 24, (1991) Abstract |
| Boerner, J., et al., Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Oncogene 22, 6679-6689, (2003) Abstract | |
| Wein, A.J., et al., Smooth Muscle Hypertrophy Following Partial Bladder Outlet Obstruction Is Associated with Overexpression of Non-Muscle Caldesmon Am. J. Pathol. 164, 601-612, (2004) Abstract | |
| Salisbury, J.L., et al., A transformation-associated complex involving tyrosine kinase signal adapter proteins and caldesmon links v-erbB signaling to actin stress fiber disassembly. Proc. Natl. Acad. Sci. U. S. A. 94, 11351-11356, (1997) Abstract |
